mamas and papas pushchairs
 

3 Types of Inhibitor

A. Nucleoside Reverse Transcriptase Inhibitor
 


1. AZT
 
 
2. ddI
3. ddC
4. Stavudine
5. Lamivudine
(3TC)
6. Abacavir

200 mg po or IV tds
 
 
125-250 mg bd
0.75 mg q8h
30-40 mg bd
150 mg bd 
 
 
300 mg bd

Bone marrow suppression (anaemia, granulocytopenia), headache, malaise, nausea
Pancreatitis, peripheral neuropathy, minor GI and CNS symptoms 
Peripheral neuropathy, oral ulcers, minor GI and CNS symptoms
Peripheral neuropathy, minor GI and CNS symptoms
Well-tolerated, minor GI and CNS symptoms reported may be due to AZT rather than 3TC. Pancreatitis was reported in 15% of patients in paediatric trials
3% develop hypersensitivity reaction: fever malaise, rash, GI symptoms.


 
B. Non-Nucleoside Reverse Transcriptase Inhibitor
 


1. Nevirapine
 
 
2. Delaviridine
 
 
3. Efavirenz

200 mg po (single dose), then 400 mg/day
 
 
400 mg qds
600mg once daily

Rash
 
 
Transient rash, P450 inhibitor
 
 
Initial dizziness, insomnia, transient rash, P450 inducer

C. HIV Protease Inhibitors
 


1. Saquinavir
2. Indivavir
3. Ritonavir
 
 
4. Nelfrinavir
5. Amprenavir

600 mg tds
800mg po tds
600 mg po bd
 
 
750 mg tds
1200 mg bd

headache, neutropenia
kidney stones, bilirubinaemia
Although side-effects are common, they are usually mild and consist mainly of GI symptoms
Diarrhoea common, which may respond to Ultrase MT20 enzyme preparations; occasional nausea
Rash (20%), diarrhoea, nausea 



Diagnostic Tests Prognostic Tests Antiviral Susceptibility Tests Treatment
3 Types of Inhibitor Monitoring anti-HIV therapy Prevention